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Qin Group

Our lab combined chemical and pharmacological approaches to endeavor to discover and develop Proteolysis Targeting Chimera (PROTAC)-based lead compounds and drugs.

PROTAC

Discovery and development of Proteolysis Targeting Chimera (PROTAC)-based lead compounds and drugs
PROTAC

CRPC

Research on therapeutic drugs for Castration-Resistant Prostate Cancer
CRPC

MBS

Discovery and development of medicinal properties and improvement of druggability of Marine Biogenic Substances
MBS

PUBLICATIONS

12. Novel Sulfonylurea-Based NLRP3 Inflammasome Inhibitor for Efficient Treatment of Nonalcoholic Steatohepatitis, Endotoxic Shock, and Colitis.

Zhuoyue Li+, Yiming Chen+, Xiaolin Jiang+, Penghui Lu, Chengli Wang, Zhimin Li, Xinyue Yu, Zixuan Yang, Shumin Ma, Shanshan Du, Zhengfu Tai, Xiaoyang Li*, Siqi Zhang*, Yuqi Jiang*, Chong Qin*

J. Med. Chem.2023, ASAP. DOI:10.1021/acs.jmedchem.3c00894



11. Discovery of BWA-522, a First-in-Class and Orally Bioavailable PROTAC Degrader of the Androgen Receptor Targeting N-Terminal Domain for the Treatment of Prostate Cancer.

Bowen Zhang+, Chang Liu+, Zhenqian Yang+, Sai Zhang+, Xiaolin Hu, Baohu Li, Mei Mao, Xiao Wang, Zhuoyue Li, Shumin Ma, Siqi Zhang, Chong Qin*

J. Med. Chem.2023, 66, 11158



10. Design, Synthesis and Biological Evaluation of Androgen Receptor (AR) Antagonist-Heat Shock Protein 90 (Hsp90) Inhibitor Conjugates for Targeted Therapy of Castration-Resistant Prostate Cancer.

Siqi Zhang+, Xiaolei Meng+, Sai Zhang+, Baohu Li, WencongJin, Chengwei Zhang, Zhaojuan Liu, Xiaolin Hu, Ling Ge, Zhonghao Yu, Zhuoyue Li, Shumin Ma, Xiao Wang, Liming Li, Chong Qin*

J. Med. Chem.2023, 66, 4784



9. Inhibition of Astrocytic Carbohydrate Sulfotransferase 15 Promotes Nerve Repair After Spinal Cord Injury via Mitigation of CSPG Mediated Axonal Inhibition.

Liming Li+*, Heping Zheng+, Xuepei Ma, Jie Bai, Shumin Ma, Zhuoyue Li, Chong Qin*.  

Cell. Mol. Neurobiol. 2023, doi: 10.1007/s10571-023-01333-9



8. Lethal Activity of BRD4 PROTAC Degrader QCA570 Against Bladder Cancer Cells. 

Qiang Wang, Baohu Li, Wenkai Zhang, Zhuoyue Li, Bo Jiang*, Sichuan Hou*, Shumin Ma*, Chong Qin*

Front. Chem. 2023, 11, 1121724



7. PROTAC Degraders of Androgen Receptor-Integrated Dissolving Microneedles for Androgenetic Alopecia and Recrudescence Treatment via Single Topical Administration.

Ruxuan Wang, Tengjiang Zhong, QiongBian, Sai Zhang, Xiaolu Ma, Liming Li, Yihua Xu, Yueting Gu, Anran Yuan, Weitong Hu, Chong Qin*, Jianqing Gao*

Small Methods. 2023, 7, 2201293



6. Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression. 

Chong Qin,+Yang Hu,+ Bing Zhou,+... Shaomeng Wang*

J. Med. Chem. 2018, 61, 6685–6704



5. Splitting a Substrate into Three Parts: Gold-Catalyzed Nitrogenation of Alkynes by C-C and C≡C Bond Cleavage. 

Chong Qin+, Yijin Su+,  Xiaodong Shi, Ning Jiao*

Angew. Chem. Int. Ed. 2016, 55, 350-354



4. Highly Selective Csp2-Csp Bond Cleavage: The Nitrogenation of Alkynes to Amides.

Chong Qin, Peng Feng, Yang Ou, Tao Shen, Teng Wang, Ning Jiao*

Angew. Chem. Int. Ed. 2013, 52, 7850-7854



3. FeCl2-promoted Unactivated C-C Bond Cleavage of Alkylarenes and Polystyrene: Direct Synthesis of Versatile Arylamines.

Chong Qin, Tao Shen, Conghui Tang, Ning Jiao*

Angew. Chem. Int. Ed. 2012, 51, 6971-6975



2. Iron-catalyzed C-H and C-C Bond Cleavage: A Direct Approach to Amides from Simple Hydrocarbon Molecules.

Chong Qin, Wang Zhou, Feng Chen, Yang Ou, Ning Jiao*

Angew. Chem. Int. Ed. 2011, 50, 12595-12599



1. Iron-Facilitated Direct Oxidative C−H Transformation of Allylarenes or Alkenes to Alkenyl Nitriles. 

Chong Qin, Ning Jiao*

J. Am. Chem. Soc. 2010, 132, 15893-15895


QIN

Professor Chong QIN, PhD

Doctoral Supervisor of School of Medicine and Pharmacy, Ocean University of China

Vice Dean of Marine Biomedical Research Institute of Qingdao



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Education


2010-2015        PhD, Medicinal Chemistry, Peking University (advisor: Prof. Ning JIAO)

2006-2010        BS, Applied Chemistry, China Agricultural University



Professional Experience


2022-                Vice Dean, Marine Biomedical Research Institute of Qingdao

2019-                Professor, Ocean University of China, School of Medicine and Pharmacy

2016-2019        Postdoctoral Fellow, College of Pharmacy, University of Michigan (advisor: Prof. Shaomeng WANG)



Academic Services


                         Reviewer of J. Med. Chem., etc.



Honors and Awards


2019                 The First Class Prize of the Beijing Science and Technology Award

2014                 May 4th Medals for Students, Peking University



Projects


2022-2025        Young Scientist Project, the National Key Research and Development Program of China, hosting

2022-2024        Youth Project, National High-level Talents Program, hosting

2022-2024        Youth Fund, the National Natural Science Foundation of China, hosting

2022-2024        Excellent Young Scientists Fund, Natural Science Foundation of Shandong, hosting

2020-2024        Youth Taishan Scholar, Shandong Government, hosting


TEAM

Professor Chong QIN, PhD

Professor Chong QIN, PhD

Principal Investigator
qc@ouc.edu.cn

FACULTY

Tengjiang ZHONG(钟腾江), MS
Tengjiang ZHONG(钟腾江), MS Zhejiang University of Technology R&D Engineer 873741902@qq.com
Sai ZHANG(张赛), MS
Sai ZHANG(张赛), MS Xi'an Jiaotong University Faculty zhangsai@qdmbri.com
Xiao WANG(王霄), PhD
Xiao WANG(王霄), PhD Peking University Postdoctoral Fellow wx1024@ouc.edu.cn
Zhuoyue LI(李卓悦), PhD
Zhuoyue LI(李卓悦), PhD Auburn University Postdoctoral Fellow lzy@ouc.edu.cn
Shumin MA(马树敏), PhD
Shumin MA(马树敏), PhD University of Chinese Academy of Sciences R&D Engineer mashumin@ouc.edu.cn
Jiaxin TANG(唐佳欣)
Jiaxin TANG(唐佳欣) Shandong Management University Purchasing Assistant tangjiaxin@baiyyy.com.cn

STUDENT

Mengjun MA(马梦君), MS
Mengjun MA(马梦君), MS Academy of Military Medical Sciences AMS PLA PhD Candidate mengjun@stu.ouc.edu.cn
Yan LV(吕燕), MS
Yan LV(吕燕), MS Shandong University PhD Candidate 605531611@qq.com
Yiming CHEN(陈怡铭), MS
Yiming CHEN(陈怡铭), MS Weifang Medical University PhD Candidate 17865651136@163.com
Zhaojuan LIU(刘兆娟), BS
Zhaojuan LIU(刘兆娟), BS Ocean University of China PhD Candidate 11220813024@stu.ouc.edu.cn
Bowen ZHANG(张博闻), MS
Bowen ZHANG(张博闻), MS Shenyang Pharmaceutical University PhD Candidate 11210811011@stu.ouc.edu.cn
Yifan WANG(王一帆), MS
Yifan WANG(王一帆), MS Xiangtan University PhD Candidate qdwyfivan@tom.com
Ling GE(葛玲), MS
Ling GE(葛玲), MS Peking University PhD Candidate geling@stu.ouc.edu.cn
Heping ZHENG(郑和平), MS
Heping ZHENG(郑和平), MS Ocean University of China PhD Candidate zhengheping@stu.ouc.edu.cn
Xiaolei MENG(孟晓蕾),  MS
Xiaolei MENG(孟晓蕾), MS Ocean University of China PhD Candidate mengxiaolei@stu.ouc.ed u.cn
Xiaoyu CHEM(陈晓宇), BS
Xiaoyu CHEM(陈晓宇), BS Qingdao University of Science and Technology MS Candidate 4022010143@mails.qust. edu.cn
Mengyao LI(李梦瑶), BS
Mengyao LI(李梦瑶), BS Chengdu University of Technology MS Candidate limy0118@163.com
Chang LIU(刘畅), BS
Chang LIU(刘畅), BS Liaoning University MS Candidate 21210811067@stu.ouc.edu.cn
Xiaolin JIANG(姜晓琳), BS
Xiaolin JIANG(姜晓琳), BS Shandong University of Traditional Chinese Medicine MS Candidate jiangxiaolin_1011@163.com
Xiaolin HU(胡晓琳), BS
Xiaolin HU(胡晓琳), BS Shandong University of Traditional Chinese Medicine MS Candidate 21210813113@stu.edu.cn
Zikun ZHOU(周子坤), BS
Zikun ZHOU(周子坤), BS Shandong University of Traditional Chinese Medicine MS Candidate zzk17860504791@163.com
Menglu HOU(侯梦露), BS
Menglu HOU(侯梦露), BS Qingdao University of Science and Technology MS Candidate 1713183815@qq.com
Zixuan YANG(杨子萱), BS
Zixuan YANG(杨子萱), BS Xi'an University of Technology MS Candidate yangzixuan@stu.ouc.edu.cn
Zhenqian YANG(杨振乾), BS
Zhenqian YANG(杨振乾), BS Heilongjiang University MS Candidate 21210813017@stu.ouc.edu.cn
Chengwei ZHANG(张成玮),  BS
Chengwei ZHANG(张成玮), BS Shandong University of Traditional Chinese Medicin MS Candidate 2397107803@qq.com
Penghui LU(卢鹏辉), BS
Penghui LU(卢鹏辉), BS Shandong First Medical University MS Candidate 21210811029@stu.ouc.edu.cn
Mei MAO(毛梅), BS
Mei MAO(毛梅), BS Ocean University of China MS Candidate maomei@stu.ouc.edu.cn
Wenjia NIU(牛文嘉), BS
Wenjia NIU(牛文嘉), BS Ocean University of China Ocean University of China niuwenjia@stu.ouc.edu.cn
Shanwen YUAN(袁善文), BS
Shanwen YUAN(袁善文), BS Qingdao University of Science and Technology MS Candidate 21220811078@stu.ouc.edu.cn
Wei ZHAN(展伟), BS
Wei ZHAN(展伟), BS Qilu University of Technology MS Candidate zhanwei20000817@163.com
Shan GAO(高姗), BS
Shan GAO(高姗), BS Jinan University MS Candidate 862443732@qq.com
Gaoxin DAI(代高鑫), BS
Gaoxin DAI(代高鑫), BS Qingdao University of Science and Technology MS Candidate xiongmaodangaox@163. com
Xuan CHEN(陈璇),BS
Xuan CHEN(陈璇),BS Qingdao University of Science and Technology MS Candidate 21230813108@stu.ouc.edu.cn
Yan MA(马岩),BS
Yan MA(马岩),BS Qingdao University of Science and Technology MS Candidate mayan5217@stu.ouc.edu.cn
Qi HE(和琦),BS
Qi HE(和琦),BS Kunming University of Science and Technology MS Candidate 21230813006@stu.ouc.edu.cn
Shuangshuang NIE(聂霜霜),BS
Shuangshuang NIE(聂霜霜),BS Qingdao University of Science and Technology MS Candidate 21230813072@stu.ouc.edu.cn
Ting CAI(蔡婷),BS
Ting CAI(蔡婷),BS Yancheng Teachers University MS Candidate 21230813018@stu.ouc.edu.cn
Miaoyuan YANG(杨苗原),BS
Miaoyuan YANG(杨苗原),BS China Three Gorges University MS Candidate 21230811011@stu.ouc.edu.cn
Bingjie YIN(尹冰洁),BS
Bingjie YIN(尹冰洁),BS Zhejiang Ocean University MS Candidate 21230811076@stu.ouc.edu.cn

FORMER MEMBER

Siqi ZHANG(张思琪), PhD
Siqi ZHANG(张思琪), PhD Ocean University of China Postdoctoral Fellow s.q.z@foxmail.com
Xinxin ZHANG(张欣欣), BS
Xinxin ZHANG(张欣欣), BS Shandong University Faculty zxx6199@ouc.edu.com
Wencong JIN(金文聪), MS
Wencong JIN(金文聪), MS Ocean University of China MS Graduate jinwencong1997@163.com
Jie BAI(白洁), MS
Jie BAI(白洁), MS Ocean University of China MS Graduate 1528408231@qq.com
Baohu LI(李宝虎), MS
Baohu LI(李宝虎), MS Anhui University of Technology MS Graduate tigerleechina@163.com
Xuepei MA(马学沛), MS
Xuepei MA(马学沛), MS Jining Medical University MS Graduate xuepeima@163.com
Wenkai ZHANG(张文开), MS
Wenkai ZHANG(张文开), MS Lanzhou University of Technology MS Graduate 17663912669@163.com
Qiang WANG(王强), MS
Qiang WANG(王强), MS Qingdao University MS Graduate wang_q072@163.com

ALBUM

FACULTY

测试~1
测试~1 Ocean University of China Postdoctoral Fellow 1122@foxmail.com

STUDENT

测试~2
测试~2 Ocean University of China Postdoctoral Fellow 1122@foxmail.com

FORMER MEMBER

测试~3
测试~3 Ocean University of China Postdoctoral Fellow 1122@foxmail.com

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Ocean University of China (Fushan Campus)

Hong Kong East Road No. 23, Qingdao, Shandong, China

Marine Biomedical Research Institute of Qingdao

Room C303

E-mail: qc@ouc.edu.cn



Ocean University of China (Fushan Campus)

Hong Kong East Road No. 23, Qingdao, Shandong, China

Marine Biomedical Research Institute of Qingdao

Room C303

E-mail: qc@ouc.edu.cn

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