14. A Potent SOS1 PROTAC Degrader with Synergistic Efficacy in Combination with KRAS^G12C Inhibitor.

Yan Lv+, Zixuan Yang+, Yiming Chen+, Xuepei Ma, Mengqi Guo, Chengwei Zhang, Xiaolin Jiang, Chengli Wang, Zhuoyue Li, Zhengfu Tai, Xiao Wang, Siqi Zhang*, Shumin Ma*, Chong Qin*

J. Med. Chem. 2024, 67, 2487

13. Discovery of Novel 2,3-Dihydro-1H-indene-5-sulfonamide NLRP3 Inflammasome Inhibitors Targeting Colon as a Potential Therapy for Colitis.

Simin Sun+, Zhuoyue Li+, Chao Huang, Jinyu Liu, Qixin Yu, Xiaolin Jiang, Kairui Yue, Jianchun Zhao, Tongqiang Xu, Yankai Liu, Xiaoyang Li*, Chong Qin*, Yuqi Jiang*.

J. Med. Chem. 2023, 66, 16141

12. Novel Sulfonylurea-Based NLRP3 Inflammasome Inhibitor for Efficient Treatment of Nonalcoholic Steatohepatitis, Endotoxic Shock, and Colitis.

Zhuoyue Li+, Yiming Chen+, Xiaolin Jiang+, Penghui Lu, Chengli Wang, Zhimin Li, Xinyue Yu, Zixuan Yang, Shumin Ma, Shanshan Du, Zhengfu Tai, Xiaoyang Li*, Siqi Zhang*, Yuqi Jiang*, Chong Qin*

J. Med. Chem. 2023, 66, 12966

11. Discovery of BWA-522, a First-in-Class and Orally Bioavailable PROTAC Degrader of the Androgen Receptor Targeting N-Terminal Domain for the Treatment of Prostate Cancer.

Bowen Zhang+, Chang Liu+, Zhenqian Yang+, Sai Zhang+, Xiaolin Hu, Baohu Li, Mei Mao, Xiao Wang, Zhuoyue Li, Shumin Ma, Siqi Zhang, Chong Qin*

J. Med. Chem. 2023, 66, 11158

10. Design, Synthesis and Biological Evaluation of Androgen Receptor (AR) Antagonist-Heat Shock Protein 90 (Hsp90) Inhibitor Conjugates for Targeted Therapy of Castration-Resistant Prostate Cancer.

Siqi Zhang+, Xiaolei Meng+, Sai Zhang+, Baohu Li, WencongJin, Chengwei Zhang, Zhaojuan Liu, Xiaolin Hu, Ling Ge, Zhonghao Yu, Zhuoyue Li, Shumin Ma, Xiao Wang, Liming Li, Chong Qin*

J. Med. Chem.2023, 66, 4784

9. Inhibition of Astrocytic Carbohydrate Sulfotransferase 15 Promotes Nerve Repair After Spinal Cord Injury via Mitigation of CSPG Mediated Axonal Inhibition.

Liming Li+*, Heping Zheng+, Xuepei Ma, Jie Bai, Shumin Ma, Zhuoyue Li, Chong Qin*.  

Cell. Mol. Neurobiol. 2023, doi: 10.1007/s10571-023-01333-9

8. Lethal Activity of BRD4 PROTAC Degrader QCA570 Against Bladder Cancer Cells. 

Qiang Wang, Baohu Li, Wenkai Zhang, Zhuoyue Li, Bo Jiang*, Sichuan Hou*, Shumin Ma*, Chong Qin*

Front. Chem. 2023, 11, 1121724

7. PROTAC Degraders of Androgen Receptor-Integrated Dissolving Microneedles for Androgenetic Alopecia and Recrudescence Treatment via Single Topical Administration.

Ruxuan Wang, Tengjiang Zhong, QiongBian, Sai Zhang, Xiaolu Ma, Liming Li, Yihua Xu, Yueting Gu, Anran Yuan, Weitong Hu, Chong Qin*, Jianqing Gao*

Small Methods. 2023, 7, 2201293

6. Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression. 

Chong Qin,+Yang Hu,+ Bing Zhou,+... Shaomeng Wang*

J. Med. Chem. 2018, 61, 6685–6704

5. Splitting a Substrate into Three Parts: Gold-Catalyzed Nitrogenation of Alkynes by C-C and C≡C Bond Cleavage. 

Chong Qin+, Yijin Su+,  Xiaodong Shi, Ning Jiao*

Angew. Chem. Int. Ed. 2016, 55, 350-354

4. Highly Selective Csp2-Csp Bond Cleavage: The Nitrogenation of Alkynes to Amides.

Chong Qin, Peng Feng, Yang Ou, Tao Shen, Teng Wang, Ning Jiao*

Angew. Chem. Int. Ed. 2013, 52, 7850-7854

3. FeCl2-promoted Unactivated C-C Bond Cleavage of Alkylarenes and Polystyrene: Direct Synthesis of Versatile Arylamines.

Chong Qin, Tao Shen, Conghui Tang, Ning Jiao*

Angew. Chem. Int. Ed. 2012, 51, 6971-6975

2. Iron-catalyzed C-H and C-C Bond Cleavage: A Direct Approach to Amides from Simple Hydrocarbon Molecules.

Chong Qin, Wang Zhou, Feng Chen, Yang Ou, Ning Jiao*

Angew. Chem. Int. Ed. 2011, 50, 12595-12599

1. Iron-Facilitated Direct Oxidative C−H Transformation of Allylarenes or Alkenes to Alkenyl Nitriles. 

Chong Qin, Ning Jiao*

J. Am. Chem. Soc. 2010, 132, 15893-15895